Cellular Structures and Functions

Histology, the study of the microscopic structure of cells, tissues, and organs, uncovers how these entities maintain the vitality of organisms. At the cellular level, each cell functions as a fundamental unit of life, encapsulated by a plasma membrane which distinguishes its boundaries. Within, the cytoplasm houses various organelles, each with distinct roles, all suspended in the cytosol—the aqueous part of the cytoplasm.


The Nucleus: Considered the control center, it governs cellular activity by directing protein synthesis and contains most of the cell's genetic material in the form of DNA. Learn more about the cell nucleus and its function at Kenhub.


Mitochondria: Known as the powerhouse, mitochondria produce chemical energy in the form of ATP, which is vital for the survival of cells.


Ribosomes: These molecular machines are responsible for protein synthesis, reading RNA transcripts and assembling proteins, essential for cellular functions.


Endoplasmic Reticulum (ER): The ER has a twofold function, with a rough part studded with ribosomes for protein synthesis and a smooth part that synthesizes lipids and detoxifies certain chemicals.


Golgi Apparatus: This organelle modifies, sorts, and packages proteins and lipids for delivery to targeted destinations.


Lysosomes: They contain enzymes that break down and digest unneeded cellular components.


At a broader anatomical perspective, tissues emerge from a collective of cells specialized for a common function, which then integrates to form organs, each performing a specific task essential to an organism's health. Glycoproteins, for instance, are critical at both cellular and tissue levels, acting in cell adhesion and recognition, thereby contributing to the overall structural and functional cohesion within an organ system.


Understanding these components at the microscopic level illuminates the elegant complexity of biological systems and reinforces the central role of histology in the study of anatomy and physiology.


December 13, 2024
1. Three-Dimensional (3D) Cell Culture Techniques : New 3D cell culture methods have significantly improved the properties of stem cells, enhancing their viability and functionality for tissue regeneration. These techniques allow for more accurate modeling of tissue architecture and function. 2. Engineered Stem Cells : Advances in bioengineering have led to the development of "engineered stem cells," which are modified to enhance their regenerative capabilities. These next-generation stem cells are designed to be more effective in tissue repair and regeneration. 3. Injectable Biomimetic Hydrogels : Researchers have developed advanced injectable hydrogels that mimic natural tissue environments. These hydrogels hold significant promise for tissue engineering applications, providing a supportive matrix for stem cell growth and differentiation. 4. Integration with Tissue Scaffolds : There have been significant improvements in integrating stem cells with biomaterial scaffolds. These scaffolds provide structural support and enhance the differentiation and growth of stem cells into specific tissue types, improving the outcomes of regenerative treatments. 5. Gene Editing and mRNA Technologies : Techniques like CRISPR and mRNA-based therapies are being used to modify stem cells at the genetic level, enhancing their ability to regenerate tissues. These technologies allow for precise control over stem cell behavior and function.
December 13, 2024
The MTM lab has experienced considerable growth over the last several years at the University of Illinois Chicago!
December 12, 2024
2024 The MTM Lab has been awarded an NIDDK R01 (National Institute of Diabetes and Digestive and Kidney Diseases) grant to develop a novel microfluidic approach to elucidate the effects of soluble factor gradients, individually and in controlled combinations, on zonated functions in primary liver cells from rodents and humans towards determining species-specific effects . Ultimately, our novel devices can be used to investigate the mechanisms underlying liver zonation, chemical-induced zonated hepatotoxicity, and how zonation is perturbed in liver diseases, such as non-alcoholic fatty liver disease and hepatocellular carcinoma. The MTM Lab has been awarded a NIEHS (National Institute of Environmental Health Sciences) grant to develop a high throughput system to test placental cell invasion using a 3D placental microtissue coupled with hepatic liver biotransformation . This first-of-its-kind hepatic-placenta organ-tandem on a chip will simulate the liver metabolism that chemicals undergo in vivo prior to reaching the placental bed. This state-of-the-art in vitro platform will be the first step towards incorporating organism-level organization into reproductive risk assessment using a non-animal-based approach. The MTM Lab has been awarded a NIEHS (National Institute of Environmental Health Sciences) grant to develop a human gut-liver platform with microbiome interactions for in vitro toxicology . These first-of-its-kind scalable human gut-liver models will be developed for in vitro applications, such as compound screening and disease modeling, and be used to elucidate the effects of reciprocal tissue crosstalk on cell phenotype modulation. 2023 The MTM Lab has been awarded a NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) grant to analyze the synergistic effects of extracellular matrix composition and stiffness, multicellular interactions, and soluble triggers of NAFLD in cellular phenotypic alterations , which could aid the development of novel drug therapies for this disease. The MTM Lab has been awarded a NIAAA (National Institute on Alcohol Abuse and Alcoholism) grant to develop a first-of-its-kind organotypic mouse liver model and investigate the effects of alcohol on multiple liver cell types in this model with comparisons to an in vivo mouse model of ALD that recapitulates several key features of human ALD. This platform can aid in understanding the molecular mechanisms underlying alcohol-associated liver disease.
More Posts