The Liver: An Overlooked Organ with Critical Functions for Maintaining Health

The liver is an indispensable organ with multiple critical functions that are vital for maintaining health. Its role impacts nearly every aspect of the body's metabolism and essential physiological processes.


Metabolism and Energy Production

The liver plays a central role in metabolism by managing energy production from nutrients. It regulates the balance and production of glucose, converting excess glucose into glycogen for storage, and releasing it into the bloodstream to keep energy levels steady.


Bile Production and Digestion

Bile production is another pivotal function. The liver produces bile, which is essential for digestion, especially in breaking down fats. Stored in the gallbladder, bile is then released into ducts within the small intestine when needed.


Detoxification and Waste Removal

Responsible for detoxification, the liver filters toxins from the blood, including alcohol, and expels them from the body. The organ's capability to neutralize harmful substances is crucial for preventing damage to other tissues and organs.


Protein Synthesis and Blood Clotting

The liver is essential for synthesizing various proteins required by the body, such as albumin. It also plays a key role in blood clotting, producing factors necessary for clot formation and utilizing vitamin K to create proteins that help in this process.


Storage of Vitamins and Minerals

This organ serves as a storage site for important vitamins and minerals, including iron and copper. The liver helps in storing vitamins A, D, E, K, and B12, and releases them as needed to sustain various body functions.


Regeneration and Healing

The liver has a remarkable ability to regenerate after injury, which ensures its continued function even after significant tissue loss. This ability is key to its resilience and is unique among the body's organs.


Immune Function and Disease Prevention

Lastly, the liver aids in immune function and disease prevention. It houses Kupffer cells, which are specialized cells that engulf potential threats like bacteria in the blood, helping to maintain overall health and prevent infections.

December 13, 2024
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December 13, 2024
The MTM lab has experienced considerable growth over the last several years at the University of Illinois Chicago!
December 12, 2024
2024 The MTM Lab has been awarded an NIDDK R01 (National Institute of Diabetes and Digestive and Kidney Diseases) grant to develop a novel microfluidic approach to elucidate the effects of soluble factor gradients, individually and in controlled combinations, on zonated functions in primary liver cells from rodents and humans towards determining species-specific effects . Ultimately, our novel devices can be used to investigate the mechanisms underlying liver zonation, chemical-induced zonated hepatotoxicity, and how zonation is perturbed in liver diseases, such as non-alcoholic fatty liver disease and hepatocellular carcinoma. The MTM Lab has been awarded a NIEHS (National Institute of Environmental Health Sciences) grant to develop a high throughput system to test placental cell invasion using a 3D placental microtissue coupled with hepatic liver biotransformation . This first-of-its-kind hepatic-placenta organ-tandem on a chip will simulate the liver metabolism that chemicals undergo in vivo prior to reaching the placental bed. This state-of-the-art in vitro platform will be the first step towards incorporating organism-level organization into reproductive risk assessment using a non-animal-based approach. The MTM Lab has been awarded a NIEHS (National Institute of Environmental Health Sciences) grant to develop a human gut-liver platform with microbiome interactions for in vitro toxicology . These first-of-its-kind scalable human gut-liver models will be developed for in vitro applications, such as compound screening and disease modeling, and be used to elucidate the effects of reciprocal tissue crosstalk on cell phenotype modulation. 2023 The MTM Lab has been awarded a NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases) grant to analyze the synergistic effects of extracellular matrix composition and stiffness, multicellular interactions, and soluble triggers of NAFLD in cellular phenotypic alterations , which could aid the development of novel drug therapies for this disease. The MTM Lab has been awarded a NIAAA (National Institute on Alcohol Abuse and Alcoholism) grant to develop a first-of-its-kind organotypic mouse liver model and investigate the effects of alcohol on multiple liver cell types in this model with comparisons to an in vivo mouse model of ALD that recapitulates several key features of human ALD. This platform can aid in understanding the molecular mechanisms underlying alcohol-associated liver disease.
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